Asked by Fabiola Morales on May 08, 2024
Verified
Mutations in BRCA1 and BRCA2 ____.
A) lead to increased telomerase activity
B) give rise to neoplasms in the breast
C) cause cells to become senescent
D) arrest cell cycle progression
E) cause cells to undergo apoptosis
BRCA1
A gene located on chromosome 17, playing a critical role in the repair of DNA breaks; mutations can significantly increase the risk of breast and ovarian cancer.
BRCA2
A gene located on chromosome 13 that produces a protein involved in DNA repair and plays a key role in maintaining the genetic stability of cells.
- Differentiate between malignant and benign (neoplastic) cellular proliferations.
- Comprehend the function of tumor suppressor genes and oncogenes in regulating the cell cycle and the development of tumors.
Verified Answer
ZK
Zybrea KnightMay 09, 2024
Final Answer :
B
Explanation :
Mutations in BRCA1 and BRCA2 are associated with an increased risk of developing neoplasms, especially in the breast and ovaries. They are involved in DNA repair and their loss of function can lead to genomic instability and the accumulation of mutations that can contribute to cancer development. There is no evidence that these mutations lead to increased telomerase activity, cause cells to become senescent, arrest cell cycle progression or cause cells to undergo apoptosis in the absence of additional factors.
Learning Objectives
- Differentiate between malignant and benign (neoplastic) cellular proliferations.
- Comprehend the function of tumor suppressor genes and oncogenes in regulating the cell cycle and the development of tumors.