The combination of physiological dependence and withdrawal symptoms is usually referred to as​

A) ​tolerance.
B) ​addiction.
C) ​psychological addiction.
D) ​psychological dependence.

Physiological dependence and withdrawal symptoms are key components of addiction, which is characterized by compulsive drug-seeking behavior despite negative consequences. Tolerance refers to the body's decreased response to a drug over time with repeated use, while psychological addiction and psychological dependence involve the craving or need for a drug based on emotional or mental factors rather than physical ones.