Asked by Ajaypal Singh on May 16, 2024
Verified
Which of the following taken in combination with the enzyme tyramine (found in yeast, chocolate and beer) can cause a life-threatening increase in blood pressure?
A) monoamine oxidase inhibitors (MAOIs)
B) Prozac
C) tricyclics (TCAs)
D) selective serotonin reuptake inhibitors (SSRIs)
E) lithium
Monoamine Oxidase Inhibitors
A type of antidepressant medication that works by inhibiting the activity of certain enzyme systems in the brain, increasing levels of neurotransmitters.
Tyramine
A naturally occurring monoamine compound found in certain foods that can affect blood pressure and is particularly relevant for individuals taking MAOI antidepressants.
Blood Pressure
The force exerted by circulating blood on the walls of blood vessels, typically measured in millimeters of mercury (mmHg).
- Recognize and categorize different types of psychoactive substances.
- Assess the potential for negative effects when using various antidepressants in the elderly population.
Verified Answer
EO
Edhere Omoefe yuleMay 16, 2024
Final Answer :
A
Explanation :
The enzyme tyramine is normally broken down in the body by an enzyme called monoamine oxidase (MAO). However, some medications such as monoamine oxidase inhibitors (MAOIs) can inhibit this enzyme, leading to a buildup of tyramine in the body. This can cause a sudden and dangerous increase in blood pressure, known as hypertensive crisis. Therefore, taking tyramine-containing foods or drinks (such as yeast, chocolate, and beer) while on MAOIs can be life-threatening.
Learning Objectives
- Recognize and categorize different types of psychoactive substances.
- Assess the potential for negative effects when using various antidepressants in the elderly population.