Asked by Ashley Flores on Jul 11, 2024
Verified
Which of the following reagents is used to protect the amino group of the N-terminal residue in solution-phase peptide synthesis?
A) lithium diisopropyl amide
B) benzyl chloroformate
C) phenyl isothiocyanate
D) dicyclohexylcarbodiimide
E) trifluoroacetic acid
Benzyl Chloroformate
An organic compound used as a reagent in the synthesis of peptides, characterized by the presence of a benzyl group attached to chloroformate.
Amino Group
A functional group consisting of a nitrogen atom bonded to one or more hydrogen atoms, typically represented as -NH2 in organic compounds.
- Identify and apply the correct procedures for protecting groups in peptide synthesis.
Verified Answer
ZK
Zybrea KnightJul 15, 2024
Final Answer :
B
Explanation :
Benzyl chloroformate (also known as Z-Cl) is commonly used to protect the N-terminal amino group in solution-phase peptide synthesis. It reacts with the amino group to form a carbamate, which can be removed later by treatment with a mild base. The other reagents listed are not used for N-terminal protection, but rather for other steps in the peptide synthesis process.
Learning Objectives
- Identify and apply the correct procedures for protecting groups in peptide synthesis.
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