Which of the following has a significant influence on how successfully a message is sent and received among people of varying backgrounds?

A) Timing
B) Manners
C) Culture
D) Competency
E) Skill

Culture plays a significant role in how messages are interpreted and received among people of varying backgrounds. Different cultural backgrounds can have different communication styles, norms, and values that can affect how a message is perceived. Therefore, it's important to consider cultural sensitivity when communicating with people from diverse backgrounds. The other options (timing, manners, competency, and skill) are all important factors in effective communication, but they don't have as significant an influence as cultural differences.