Which of the following body defences against infection works by interfering with the replication of a virus?

A) Phagocyte
B) Interferon
C) Macrophage
D) Helminths

Interferons are proteins produced in response to viral infection. They act to interfere with the replication of the virus within infected cells, while also signaling to nearby cells to increase their antiviral defenses. Phagocytes and macrophages are types of immune cells that work to engulf and digest pathogens, but they do not specifically interfere with viral replication. Helminths are parasitic worms and not involved in antiviral defenses.