When heavy coffee drinkers skip their usual caffeine,they experience the effects of ________ when a headache strikes.

A) reuptake
B) withdrawal
C) disinhibition
D) the dopamine reward system

When heavy coffee drinkers skip their usual caffeine intake, they experience withdrawal symptoms, which can include headaches, fatigue, drowsiness, irritability, and difficulty concentrating. This is because caffeine is a stimulant that affects the brain's chemistry and can create dependence. When caffeine is no longer consumed, the brain and body experience withdrawal symptoms.