There are separate nociceptors for mechanical damage and damage due to toxic substances.

Nociceptors

Nociceptors are sensory receptors that respond to potentially harmful stimuli by sending nerve signals to the spinal cord and brain, which is interpreted as pain.

Mechanical Damage

Physical harm or injury caused to structures or materials due to external forces or stress.

Toxic Substances

Materials or compounds that cause harm to organisms when ingested, inhaled, or come into contact with skin or mucous membranes.