Asked by Yamam Flowers on May 31, 2024
Verified
The first mechanistic step in the direct reaction of an amine with a carboxylic acid to produce an amide is ________.
A) an acid-base reaction
B) nucleophilic attack on the carbonyl carbon
C) loss of H2O
D) loss of CO2
E) loss of N2
Mechanistic Step
Refers to an individual stage or transition within the broader sequence of events that constitute a chemical reaction's mechanism.
Amine
An organic compound and functional group consisting of a basic nitrogen atom with a lone pair and deriving from ammonia by replacement of one or more hydrogen atoms by organic groups.
Carboxylic Acid
Organic compounds containing a carboxyl group (-COOH), known for their acidic properties.
- Acquire knowledge and provide explanations on the mechanistic sequences integral to essential organic reactions, including but not limited to esterification and interactions concerning carboxylic acid derivatives.
Verified Answer
CN
Chrissie NelmsJun 06, 2024
Final Answer :
A
Explanation :
The first step in the reaction of an amine with a carboxylic acid is typically an acid-base reaction, where the amine acts as a base and deprotonates the carboxylic acid, forming an intermediate that can further react to form an amide.
Learning Objectives
- Acquire knowledge and provide explanations on the mechanistic sequences integral to essential organic reactions, including but not limited to esterification and interactions concerning carboxylic acid derivatives.