Ongoing, regular consumption of a substance with significant resulting clinical manifestations is known as:

A) abuse.
B) dependence.
C) use.
D) None of these

Clinical Manifestations

Observable signs, symptoms, and syndromes that arise and are indicative of a specific disease or medical condition.

Dependence

The state of relying on or needing a substance, object, or activity for physical or psychological well-being.

Substance Abuse

The damaging or dangerous consumption of psychoactive substances, like alcohol and illegal drugs.