Neuroleptics have their primary effect by increasing the activity of the neurotransmitter gamma-aminobutyric acid (GABA).

Neuroleptics, also known as antipsychotics, primarily work by blocking the activity of dopamine in the brain, which can help reduce symptoms of psychosis. They may also have effects on other neurotransmitters such as serotonin and norepinephrine. While some neuroleptics may indirectly affect GABA activity, this is not their primary mechanism of action.