Common Rule, 45 Code of Federal Regulations 46 A is a set of regulations for research involving human subjects that has been adopted by many federal departments and agencies.It sets forth a number of guidelines for researchers.Identify three ways that this common rule guides investigators and protects participants.

Common Rule requires that researchers minimize risks to study participants.As a result, researcher must design studies that only expose participants to "minimal risk," which is no greater than what the participants would encounter in daily life or during a routine doctor's office visit.Common Rule also requires each institution to have an institutional review board (IRB) to review research on human subjects.IRB protects participants by conducting a risk-benefit analysis of each study and by only permitting projects where risk is reasonable in relation to benefits.